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Metarrestin

  Cat. No.:  DC22157   Featured
Chemical Structure
1443414-10-5
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More than 5000 active chemicals with high quality for research!
Field of application
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1443414-10-5
Chemical Name: (1r,4r)-4-(7-Benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)cyclohexanol
Synonyms: trans-4-(7-Benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrr;J3.616.158B;KUC110052N;KUC109088N;KUC109037N;ML246;Q6A9F9DSX5;(1r,4r)-4-(7-benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)cyclohexanol;Metarrestin (KUC109088N);SMR002357104;MLS003678589;Metarrestin
SMILES: O([H])C1([H])C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])N1C([H])=NC2=C(C(C3C([H])=C([H])C([H])=C([H])C=3[H])=C(C3C([H])=C([H])C([H])=C([H])C=3[H])N2C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])/C/1=N/[H]
Formula: C31H30N4O
M.Wt: 474.596107006073
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis[1][2].
Target: RNA polymerase (Pol) I[1][2]
References: [1]. Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080. [2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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