VTI-1002|VTI1002|Granzyme B (GzmB) inhibitor

Cas No.:
Chemical Name:	VTI-1002
Synonyms:	VTI1002, VTI 1002
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase; VTI-1002 is nearly 20 times more potent against human GzmB than Ac-IEPD-CHO (Ki=80 nM), exhibits potent inhibition against mouse GzmB (IC50=179 nM); improves remodeling in a murine model of impaired burn wound healing.

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