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| Cas No.: | 1361993-03-4 |
| Chemical Name: | 6-bromo-N-(2-fluorophenyl)-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxamide |
| Formula: | C19H18BrFN2O3 |
| M.Wt: | 421.266 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH; demonstrates an excellent selectivity profile against a panel of cannabinoid related targets, including CB1, CB2, and VR1; demonstrates a unique nonmechanism-based inhibition of FAAH activity, which is distinct from almost all known FAAH inhibitors; shows excellent PK properties with a low clearance of 0.4 L/h/Kg and a high bioavailability of 92%. |