SPDP| CAS 68181-17-9|DC Chemicals

Cas No.:	68181-17-9
Chemical Name:	Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
SMILES:	C1=CC=C(SSCCC(ON2C(=O)CCC2=O)=O)N=C1
Formula:	C₁₂H₁₂N₂O₄S₂
M.Wt:	312.3647
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

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