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ML-210

  Cat. No.:  DC22800   Featured
Chemical Structure
1360705-96-9
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More than 5000 active chemicals with high quality for research!
Field of application
A small-molecule probe that selectively kills cells induced to express mutant RAS.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1360705-96-9
Synonyms: CID 49766530;ML-210;[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
SMILES: ClC1=CC=C(C(N2CCN(C(C3=NOC(C)=C3[N+]([O-])=O)=O)CC2)C2=CC=C(Cl)C=C2)C=C1
Formula: C22H20Cl2N4O4
M.Wt: 475.32460308075
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].
Target: Glutathione Peroxidase 4 (GPX4)[1]
References: [1]. John K. Eaton, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. Biorxiv. 2018. [2]. Weïwer M, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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