VPC 23019|CAS 449173-19-7|DC Chemicals

Cas No.:	449173-19-7
Chemical Name:	VPC 23019
Synonyms:	VPC 23019;(R)-phosphoric acid mono-[2-amino-2-(3-octyl-phenylcarbamoyl)-ethyl] ester;N-(3-Octylphenyl)-O-phosphono-D-serinamide
SMILES:	CCCCCCCCC1=CC(=CC=C1)NC(=O)[C@H](N)COP(O)(O)=O
Formula:	C₁₇H₂₉N₂O₅P
M.Wt:	372.396325826645
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].
Target:	pKi: 7.86 (S1P1); 5.93 (S1P3). pEC50: 6.58 (S1P1); 7.07 (S1P3)[1]
References:	[1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8

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