ICA-105574| CAS 316146-57-3|DC Chemicals

Cas No.:	316146-57-3
Chemical Name:	3-nitro-N-(4-phenoxyphenyl)benzamide
Synonyms:	3-nitro-N-(4-phenoxyphenyl)benzamide;3-nitro-N-[4-(phenoxy)phenyl]benzamide;ICA105574;ICA 105574;Oprea1_425613;Oprea1_777421;GTPL7656;STL377841;3-nitro-N-[4-phenoxyphenyl]-benzamide;ST50189968;(3-nitrophenyl)-N-(4-phenoxyphenyl)carboxamide;Q27078021
SMILES:	O(C1C([H])=C([H])C([H])=C([H])C=1[H])C1C([H])=C([H])C(=C([H])C=1[H])N([H])C(C1C([H])=C([H])C([H])=C(C=1[H])[N+](=O)[O-])=O
Formula:	C₁₉H₁₄N₂O₄
M.Wt:	334.3255
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM; produces comparatively small hyperpolarizing shifts (up to 11 mV) in the voltage-dependence of channel activation and a 2-fold slowing of channel deactivation; enhances IKr current with very high potency by removing the channel inactivation, prevents ventricular arrhythmias in intact guinea-pig hearts caused by IKr and IKs inhibitors, has more efficient antiarrhythmic activity than NS1643.

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