Naspm trihydrochloride| CAS 1049731-36-3|DC Chemicals

Cas No.:	1049731-36-3
Chemical Name:	1-Naphthaleneacetamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-, hydrochloride (1:3)
Synonyms:	1-Naphthylacetyl spermine trihydrochloride
SMILES:	C1(CC(NCCCNCCCCNCCCN)=O)C2C(=CC=CC=2)C=CC=1
Formula:	C₂₂H₃₇Cl₃N₄O
M.Wt:	479.9144
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

Description:

Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM; greatly reduces the late rise in intracellular free Zn(2+) in postischemic CA1 neurons and affords partial protection against ischemia-induced cell death, protects against ischemia-induced death of CA1 neurons in vivo; selectively suppresses the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons, has no effect on AMPA receptors in type I neurons.

References:

[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

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