JNJ-17203212| CAS 821768-06-3

Cas No.:	821768-06-3
Chemical Name:	1-Piperazinecarboxamide, 4-[3-(trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-
Synonyms:	JNJ17203212;JNJ 17203212
SMILES:	FC(F)(F)C1=CC=CN=C1N1CCN(C(NC2C=CC(C(F)(F)F)=CN=2)=O)CC1
Formula:	C₁₇H₁₅F₆N₅O
M.Wt:	419.3243
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.

In Vivo:

JNJ-17203212 reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. Throughout this study, colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle. [1] Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents core hypothermia evoked by sc capsaicin. Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents capsaicin-evoked hypothermia in a dose-response manner. [2]

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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DC37283	Methyl phenylcarbamate	Methyl phenylcarbamate is a biochemical.
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