Necrox-5 methanesulfonate| CAS 1383718-29-3

Cas No.:	1383718-29-3
Chemical Name:	NecroX-5
Synonyms:	NecroX-5;NecroX-5 mesylate;5-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine dimesylate;Necrox-5 (methanesulfonate);5-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-N-(oxan-4-ylmethyl)-2-phenyl-1H-indol-7-amine;methanesulfonic acid
SMILES:	S1(CCN(CC2C=C3C=C(C4C=CC=CC=4)NC3=C(C=2)NCC2CCOCC2)CC1)(=O)=O.S(C)(=O)(=O)O.S(C)(=O)(=O)O
Formula:	C₂₇H₃₉N₃O₉S₃
M.Wt:	645.808264017105
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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