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| Cas No.: | 1352609-28-9 |
| Chemical Name: | 3-[[5-(6-Methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile |
| Synonyms: | BDBM50015679;3-(((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)amino)benzonitrile;3-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile |
| SMILES: | N1([H])C(C([H])([H])N([H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])=NC(C2C([H])=C([H])C3=NC([H])=NN3C=2[H])=C1C1=C([H])C([H])=C([H])C(C([H])([H])[H])=N1 |
| Formula: | C23H18N8 |
| M.Wt: | 406.4426 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α; decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells; inhibits metastasis to lung from breast tumours in xenografted mice. |
| References: | References 1. Park CY, et al. Eur J Cancer. 2011 Nov;47(17):2642-53. View Related Products by Target TGF beta Receptor (TGFBR) Chemical & Physical Properties |
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COA
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| 2018-0101 |
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| 2018-0101 |
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