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N-Acetyl-Calicheamicin

  Cat. No.:  DC23924   Featured
Chemical Structure
108212-76-6
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More than 5000 active chemicals with high quality for research!
Field of application
N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 108212-76-6
Chemical Name: N-Acetyl-Calicheamicin
Synonyms: N-Acetyl-Calicheamicin;N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin;N-Acetyl-y-calicheamicin;N-Acetyl-Calicheamicin y
SMILES: IC1C(C)=C(C(=C(C=1O[C@H]1[C@@H]([C@@H]([C@H]([C@H](C)O1)O)OC)O)OC)OC)C(=O)S[C@@H]1[C@@H](C)O[C@H](C[C@@H]1O)ON[C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1O)O[C@H]1C[C@@H]([C@H](CO1)N(C(C)=O)CC)OC)O[C@H]1C#CC=CC#C[C@@]2(CC(C(=C1/C/2=C\CSSSC)NC(=O)OC)=O)O |c:69|
Formula: C57H76In3O22S4
M.Wt: 1410.38472557068
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic.N-Acetyl-Calicheamicin is a a derivative of Calicheamicin. Calicheamicin is a naturally occurring hydrophobic enediyne antibiotic that was isolated from the actinomycete Micromonospora echinospora calichensis. Calicheamicin can interfere with biological processes not simply by cleaving free DNA but also by displacing a DNA-binding protein through competition or modulation of DNA structure.
Target: Antibacterial
References: [1]. Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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