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Cilobradine

  Cat. No.:  DC23962   Featured
Chemical Structure
186097-54-1
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More than 5000 active chemicals with high quality for research!
Field of application
A hyperpolarization-activated cyclic nucleotide-gated (HCN) channel.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 186097-54-1
Chemical Name: 2H-3-Benzazepin-2-one,3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-,hydrochloride (1:1)
Synonyms: 2H-3-Benzazepin-2-one,3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-,hydrochloride (1:1);2H-3-Benzazepin-2-one,3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-...;2H-3-Benzazepin-2-one,3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-,hydro;3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride;DK-AH 269;3-({(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl}methyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;Cilobradine hydrochloride, (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;(S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;Cilobradine DK-AH;Cilobradine (hydrochloride);Cilobradine hydrochloride
SMILES: Cl.COC1C(OC)=CC(CCN2C[C@H](CCC2)CN3C(=O)CC4C(CC3)=CC(OC)=C(OC)C=4)=CC=1
Formula: C28H38N2O5.HCl
M.Wt: 519.07266
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.Cilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4).
Target: HCN Channel blocker
References: [1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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