STING Agonist-1 G10| CAS 702662-50-8

Cas No.:	702662-50-8
Chemical Name:	STING agonist-1
Synonyms:	STING agonist-1;G10;G10 [PMID: 26646986];4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;GTPL9206;HMS1621G10;BCP33022;s8954;4-[(2-chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide;Q27077760;4-[(2-Chloro-6-fluorophenyl;CDB66250;D83678;A918021
SMILES:	ClC1=C([H])C([H])=C([H])C(=C1C([H])([H])N1C(C([H])([H])SC2C([H])=C([H])C(C(N([H])C([H])([H])C3=C([H])C([H])=C([H])O3)=O)=C([H])C1=2)=O)F
Formula:	C₂₁H₁₆ClFN₂O₃S
M.Wt:	430.8797
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM).

In Vitro:

G10 does not bind to STING directly, however, G10 represents the first synthetic small molecule characterized as an indirect activator of human STING-dependent phenotypes.100 μM G10 (a concentration over twelve times the IC90 for CHIKV and over four times the IC90 for VEEV). G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 Induces IFN/IRF3- but not NF-κB-Dependent Transcription in Human Fibroblasts. G10 activates IRF3, but not canonical NF-κB pathways in human fibroblasts. G10 elicits antiviral activity against New and Old World Alphaviruses. G10 stimulates phosphorylation of IFN regulatory factor 3 (IRF3) in a manner similar to that triggered by UV-inactivated cytomegalovirus (UV-CMV) and Sendai virus (SeV). G10 induces synthesis and secretion of bioactive type I and III IFNs and generates an antiviral state in fibroblast cells positive for STING, IRF3, and STAT1 proteins. G10 triggers innate immune responses that involve expression of IRF3-dependent genes including type I and III interferons.

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STING Agonist-1(G-10)