USP8-IN-22e| CAS 924296-19-5

Cas No.:	924296-19-5
Chemical Name:	DUBs-IN-2
Synonyms:	DUBs-IN-2;DUB-IN-2;(9E)-9-ethoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
SMILES:	O(C([H])([H])C([H])([H])[H])/N=C1/C2C(C3=C([H])C([H])=C([H])C([H])=C3/1)=NC(C#N)=C(C#N)N=2
Formula:	C₁₅H₉N₅O
M.Wt:	275.2649
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM; shows no inhibitory activity for USP7 (IC50>100 uM).
Target:	IC50: 0.28 μM (USP8)[1]
In Vitro:	DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].
References:	[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

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