Guanosine 5'-triphosphate-5'-adenosine

Cas No.:	10527-47-6
Chemical Name:	Guanosine 5'-triphosphate-5'-adenosine
SMILES:	O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(OC[C@H]2O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@@H]([C@@H]2O)O)(O)=O)(O)=O)(O)=O)([H])N5C6=C(C(N=C(N6)N)=O)N=C5
Formula:	C20H27N10O17P3
M.Wt:	772.41
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog[1].
In Vitro:	Guanosine 5'-triphosphate-5'-adenosine (GpppA) labeled with pyrene at the 3′‐O position of adenosine acted as an artificial substrate[1]. Fluorescently labeled Guanosine 5'-triphosphate-5'-adenosine (GpppA) and GpppG analogs as potential substrates that represent a reasonable compromise between the structural complexity and requirements of the enzyme[1].
References:	[1]. Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26(49):11266-11275. [2]. Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12(12):4383-4388.