Lenalidomide hydrochloride |CAS 1243329-97-6|DC Chemicals

Cas No.:	1243329-97-6
Chemical Name:	Lenalidomide (hydrochloride)
Synonyms:	Lenalidomide (hydrochloride);CC-5013 hydrochloride;CC5013 hydrochloride;CC 5013 hydrochloride;RevliMid hydrochloride;Lenalidomide HCl;UNII-46Q7T54YCJ;1243329-97-6;Lenalidomidehydrochloride;AKOS030526351;RYWZLJSDFZVVTD-UHFFFAOYSA-N;DA-64913;Lenalidomide hydrochloride;3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione hydrochloride;HY-A0003A;3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;SCHEMBL1904696;TQR1045;3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrochloride;2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, hydrochloride (1:1);46Q7T54YCJ;CS-1589
SMILES:	O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O.[H]Cl
Formula:	C₁₃H₁₄ClN₃O₃
M.Wt:	295.721561908722
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC60864	D927 (DS11252927)	D927 is a molecular glue and promotes glucose uptake in the absence of insulin. D927 also increases the affinity of RAS binding to PI3Kα by ~500-fold. In vivo, D927 mimicks the effects of insulin and rapidly lowers blood glucose concentrations.
DC60863	D223 (DS02312223)	D223 is a molecular glue and promotes glucose uptake in the absence of insulin. D223 also increases the affinity of RAS binding to PI3Kα by ~500-fold.
DC60858	LC-04-045	LC-04-045 is a leading NEK7 molecular glue degrader with DC50 of 7 nM and Dmax of 90 % in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome.
DC60852	PVTX-405	PVTX-405 is a potent, effective, highly selective, and orally efficacious IKZF2 molecular glue degrader with DC50 of 0.7 nM. PVTX-405 in combination with anti-PD1 or anti-LAG3 significantly increases animal survival compared to anti-PD1 or anti-LAG3 alone.
DC60837	MGD-28	MGD-28 is a potent molecular glue degrader that demonstrates significant in vitro efficacy against various hematological cancer cell lines. It induces degradation of Ikaros family zinc finger proteins 1, 2, and 3 (IKZF1/2/3) and casein kinase 1 alpha (CK1α) with nanomolar potency via a Cullin-cereblon (CRBN) dependent pathway. Compared to lenalidomide and pomalidomide, MGD-28 achieves deeper, faster, and more potent degradation of these neosubstrates. Additionally, MGD-28 exhibits broad antiproliferative activity in multiple solid malignancies and shows preferential cytotoxicity toward multiple myeloma patient-derived cells at various disease stages.
DC67413	MRT-23227
DC67412	MRT-3486	MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research.
DC67411	MRT-7612
DC67410	MRT-10350
DC67407	IKZF1-degrader-1	IKZF1-degrader-1 (Compound 9-B) is a highly potent molecular glue that achieves sub-nanomolar degradation of IKZF1 (DC50 = 0.134 nM), demonstrating significant therapeutic potential for targeting IKZF1-dependent malignancies.