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Sitagliptin Phosphate Monohydrate

  Cat. No.:  DC75345   Featured
Chemical Structure
654671-77-9
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More than 5000 active chemicals with high quality for research!
Field of application
Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses.
Cas No.: 654671-77-9
Chemical Name: Sitagliptin phosphate monohydrate
Synonyms: (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;Sitagliptin phosphate monohydrate;Sitagliptin phosphate for research;Sitagliptin (phosphate monohydrate);Sitagliptin Monophosphate Monohydrate;Sitagliptin phosphate;Sitagliptin phosphate monohydrate (MK-0431,Januvia®);Sitagliptin phosphate;(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogenphosphate monohydrate;3(R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H [1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Januvia (tn);Sitaglipt;Sitagliptin monohydrate;Sitagliptin phosphate (usan);Sitagliptin phosphate hydrate;Sitagliptin phosphate hydrate (jan);7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate;MK-0431;SITAGLIPTIN PHOSPHATE [JAN];SITAGLIPTIN PHOSPHATE MONOHYDRATE [EP MONOGRAPH];Tesavel;JANUMET COMPONENT SITAGLIPTIN PHOSPHATE;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate Monohydrate.;SITAGLIPTIN PHOSPHATE [USP MONOGRAPH];AKOS015895530;MFCD10001393;SITAGLIPTIN PHOSPHATE HYDRATE [JAN];(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid;hydrate;HY-13749B;CCG-213562;1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate;SITAGLIPTIN PHOSPHATE [USP-RS];654671-77-9;SCHEMBL1039535;SITAGLIPTIN PHOSPHATE [VANDF];BS164409;(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-alpha]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogenphosphate monohydrate;DTXSID50904746;EX-A8379A;(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydra;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;Januvia;AMY1793;Sitagliptin phosphate hydrate (JP17);TS63EW8X6F;654671-77-9 (Phosphate hydrate);s4002;SITAGLIPTIN PHOSPHATE [ORANGE BOOK];Glactiv;SITAGLIPTIN PHOSPHATE MONOHYDRATE [WHO-DD];SITAGPLIPTINPHOSPHATEMONOHYDRATE;ONO-5435;MK0431;STELUJAN COMPONENT SITAGLIPTIN PHOSPHATE;1,2,4-TRIAZOLO(4,3-A)PYRAZINE, 7-((3R)-3-AMINO-1-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTYL)-5,6,7,8-TETRAHYDRO-3-(TRIFLUOROMETHYL), PHOSPHATE (1:1) MONOHYDRATE;7-((3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-...
SMILES: P(=O)(O)(O)O.FC(C1=NN=C2CN(C(C[C@@H](CC3C=C(C(=CC=3F)F)F)N)=O)CCN21)(F)F.O
Formula: C16H20F6N5O6P
M.Wt: 523.324085235596
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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