Elbasvir(MK-8742)|CAS 1370468-36-2|DC Chemicals

Cas No.:	1370468-36-2
Chemical Name:	Methyl N-[(2S)-1-[(2S)-2-[5-[(6S)-10-[2-[1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazin-3-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Synonyms:	MK 8742;Elbasvir;MK-8742;Methyl N-[(2S)-1-[(2S)-2-[5-[(6S)-10-[2-[1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidi
SMILES:	O=C([C@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C(=O)OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])C1=NC([H])=C(C2C([H])=C([H])C3=C(C=2[H])C([H])=C2C4C([H])=C([H])C(=C([H])C=4O[C@@]([H])(C4C([H])=C([H])C([H])=C([H])C=4[H])N23)C2=C([H]
Formula:	C₄₉H₅₅N₉O₇
M.Wt:	882.0171
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

In Vitro:

Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC90 of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses[1]. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC50s in the low-picomolar range[2].

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