Eptifibatide acetate|CAS 148031-34-9|DC Chemicals

Cas No.:	1248559-53-6
Chemical Name:	Eptifibatide acetate
Synonyms:	MPA-HAR-GDWPC-NH2
SMILES:	NC(NCCCC[C@@H]1NC(CCSSC[C@@H](C(N)=O)NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC(CNC1=O)=O)CC(O)=O)=O)Cc(c[nH]3)c4c3cccc4)=O)=O)=O)=N
Formula:	C₃₇H₅₃N₁₁O₁₁S₂
M.Wt:	892.01
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Eptifibatide, also co-promoted by Schering-Plough/Essex, is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

References:

[1]. Amoroso, G., et al., Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease. J Cardiovasc Pharmacol, 2001. 38(4): p. 633-41. [2]. Schwarz, M., et al., Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61). J Pharmacol Exp Ther, 2004. 308(3): p. 1002-11.

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