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FEN1-IN-4

  Cat. No.:  DC40961   Featured
Chemical Structure
1995893-58-7
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More than 5000 active chemicals with high quality for research!
Field of application
FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1995893-58-7
Chemical Name: 1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
Synonyms: FEN1 Inhibitor C2;FEN1-IN-4;1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
SMILES: ON1C(=O)N(CC2CC2)C3C(=CC=CC=3)C1=O
Formula: C12H12N2O3
M.Wt: 232.2353
Purity: >98%
Sotrage: Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month
Description: FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1].
Target: hFEN1[1]
In Vitro: FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1].
References: [1]. Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21.
MSDS
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COA
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