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FK962

  Cat. No.:  DC28714   Featured
Chemical Structure
283167-06-6
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More than 5000 active chemicals with high quality for research!
Field of application
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 283167-06-6
Chemical Name: FK962
Synonyms: FK-962,FK 962
SMILES: =C(NC1CCN(C(C)=O)CC1)C2=CC=C(F)C=C2
Formula: C14H17FN2O2
M.Wt: 264.3
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].
Target: Somatostatin release[1]
In Vivo: FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2] Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.
In Vitro: FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1].
References: [1]. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. [2]. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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