HS220|HS-220|CAS 1570374-32-1|DC Chemicals

Cas No.:	1570374-32-1
Chemical Name:	3-((1-propyl-1H-benzo[d]imidazol-2-yl)carbamoyl)benzoic acid
Synonyms:	HS-220;HS 220
SMILES:	C(O)(=O)C1=CC=CC(C(=O)NC2=NC3=CC=CC=C3N2CCC)=C1
Formula:	C₁₈H₁₇N₃O₃
M.Wt:	323.352
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Raphemot R, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30391-X.

Description:

HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability; induce a unique phenotype where parasite size in hepatocytes increases.

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