HZ-1157|HZ1157|CAS 1009734-33-1|DC Chemicals

Cas No.:	1009734-33-1
Chemical Name:	5-Tert-butoxyquinazoline-2,4-diaMine
Synonyms:	5-tert-butoxyquinazoline-2,4-diaMine;HZ-1157;DHFR-inhibitor;5-tert-butoxyquinazoline-2,4-diaMine 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;5-(tert-Butoxy)quinazoline-2,4-diamine;2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;AOB5039;BCP13575;BDBM50385959;AK202965;5-[(2-methylpropan-2-yl)oxy]quinazoline-2,4-diamine
SMILES:	O(C1=C([H])C([H])=C([H])C2=C1C(N([H])[H])=NC(N([H])[H])=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
Formula:	C₁₂H₁₆N₄O
M.Wt:	232.2816
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

In Vitro:

HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.

Cat. No.	Product name	Field of application
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DC46965	Tri-GalNAc-COOH	tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research.
DC46471	RP101988	RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.
DC37901	PD-173212	PD-173212 is a small molecule N-type calcium channel blocker.
DC37333	N,N-Diethyl-p-toluamide	N,N-Diethyl-p-toluamide is a mosquito repellent.
DC37321	AI3-15902	AI3-15902 is a biochemical.
DC37283	Methyl phenylcarbamate	Methyl phenylcarbamate is a biochemical.
DC37252	Ampyrone	Ampyrone is a metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.