ITSA-1 (ITSA1)|cas 200626-61-5|DC Chemicals

Cas No.:	200626-61-5
Chemical Name:	Methanone,1H-benzotriazol-1-yl(2,4-dichlorophenyl)-
Synonyms:	Methanone,1H-benzotriazol-1-yl(2,4-dichlorophenyl)-;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole;benzotriazol-1-yl-(2,4-dichlorophenyl)methanone;BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE;Inhibitor of Trichostatin A 1;Inhibitor-1 of Trichostatin A;ITSA1;ITSA-1
SMILES:	O=C(N1N=NC2=CC=CC=C21)C3=CC=C(Cl)C=C3Cl
Formula:	C₁₃H₇N₃OCl₂
M.Wt:	292.12018
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

References:

[1]. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.

Cat. No.	Product name	Field of application
DC70802	SS-208	SS-208 (SS208) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 12 nM, >100-fold selectivity over HDAC1/4/5/7/8/9/11.SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model.
DC3110	CUDC-907 (PI3K/HDAC InhibitorI)	CUDC-907 (PI3K/HDAC Inhibitor I) is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.
DC8252	Vorinostat (SAHA)	Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM.
DC8663	UF010	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
DC6303	Tubastatin A HCl	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC6304	Tubastatin A	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC5178	Tubacin (BML-GR362)	Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2).
DC8134	Trichostatin A (TSA)	Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
DC7716	TMP269	TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs.
DC10210	TMP195	TMP195 is the most potent and selective class IIa HDAC inhibitor.