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Quisinostat HCl

  Cat. No.:  DC31251   Featured
Chemical Structure
875320-31-3
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More than 5000 active chemicals with high quality for research!
Field of application
Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 875320-31-3
Chemical Name: Quisinostat dihydrochloride
Synonyms: Quisinostat 2HCl;Quisinostat dihydrochloride;Quisinostat diHCl;BCP20792;SB16529;S1096;N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride;5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-, dihydrochloride (9CI)
SMILES: Cl.O=C(C1C=NC(N2CCC(CNCC3C4C(=CC=CC=4)N(C)C=3)CC2)=NC=1)NO
Formula: C21H27ClN6O2
M.Wt: 430.931082963943
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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