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| Cas No.: | 2247481-21-4 |
| Chemical Name: | 4-[[[4-[5-Chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile |
| Synonyms: | JSH-150;JSH 150; JSH150;BCP33243;4-[[[4-[5-Chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]me |
| SMILES: | ClC1=C([H])N=C(C([H])=C1C1=C([H])SC(=N1)N([H])C([H])([H])C1(C#N)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])N([H])C([H])([H])C([H])([H])OC([H])([H])[H] |
| Formula: | C24H33ClN6O2S |
| M.Wt: | 505.0758 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM); also exhibits high selectivity over other 468 kinases/mutants (KINOMEscan S score(1) = 0.01); displays potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines, dose-dependently inhibits the phosphorylation of RNA Pol II, suppresses the expression of MCL-1 and c-Myc, arreststhe cell cycle and induces the apoptosis in the leukemia cells; completely suppresses the tumor progression in MV4-11 cell-inoculated xenograft mouse model (10 mg/kg). |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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