KL-1|KL1|SEC inhibitor|cas 900308-84-1|DC Chemicals

Cas No.:	900308-84-1
Chemical Name:	N-(5-chloro-2-methylphenyl)-4-(3-methoxyphenyl)-2,4-dioxobutanamide
Synonyms:	KL1,KL-1,KL 1
SMILES:	C1=C(OC)C=CC=C1C(CC(C(=O)NC1=CC(Cl)=CC=C1C)=O)=O
Formula:	C₁₈H₁₆ClNO₄
M.Wt:	345.08
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	N-(5-chloro-2-methylphenyl)-4-(3-methoxyphenyl)-2,4-dioxobutanamide

Description:

SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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