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| Cas No.: | 74381-53-6 |
| Chemical Name: | Leuprolide acetate |
| Synonyms: | leuprolide;Leuprolide acetate;(Des-Gly¹⁰,D-Leu⁶,Pro-NHEt⁹)-LHRH;Leuprorelin Acetate;Leuprorelin;(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino;(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-4-methyl-valeric acid;{pGLU}HWSY{d-LEU}LRP;H2N-Leu-Leu-Leu-OH;H-LEU-LEU-LEU-OH;Leucylleucylleucin;leucyl-leucyl-leucine;Leu-leu-leucrystalline;leuprolide acetate salt;L-LEUCY-L-LEUCYL-L-LEUCINE;L-LEUCYL-L-LEUCYL-L-LEUCINE;pGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro;pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C2H5;tri-leucine;TRILEUCINE;des-Gly10-[D-Leu6]-LH-RH ethylamide;Lupron;Enantone;Prostap;Carcinil;Lutrate;Onectyl;Enanton;leuprolide-acetate;DSSTox_RID_83201;DSSTox_CID_28935;DSSTox_GSID_49009;MLS000028695;RGLRXNKKBLIBQS-XNHQSDQCSA-N;Tox21_113507;SMR00005894 |
| SMILES: | O=C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])/N=C(\N([H])[H])/N([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H])N([H])C([C@]([H])(C([H])([H])O[H])N([H])C([C@]([H])(C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)N([H])C([C@]([H])(C([H])([H])C1=C([H])N=C([H])N1[H])N([H])C([C@]1([H])C([H])([H])C([H])([H])C(N1[H])=O)=O)=O)=O)=O)=O)=O)=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(N([H])C([H])([H])C([H])([H])[H])=O.O([H])C(C([H])([H])[H])=O |
| Formula: | C61H88N16O14 |
| M.Wt: | 1269.4502 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Leuprolide acetate is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids. |
| References: | [1]. Mizutani T, Sugihara A, Nakamuro K, Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate). J Clin Endocrinol Metab. 1998 Apr;83(4):1253-5. [2]. Silva AL, Abreu LG, Rosa-e-Silva AC, Leuprolide acetate reduces both in vivo and in vitro ovarian steroidogenesis in infertile women undergoing assisted reproduction. Steroids. 2008 Dec 22;73(14):1475-84. [3]. Guzmán-Soto I, Salinas E, Hernández-Jasso I, Leuprolide acetate, a GnRH agonist, improves experimental autoimmune encephalomyelitis: a possible therapy for multiple sclerosis. Neurochem Res. 2012 Oct;37(10):2190-7. [4]. Gaikwad U, Parle M, Kumar A, Effect of ritanserin and leuprolide alone and combined on marble-burying behavior of mice. Acta Pol Pharm. 2010 Sep-Oct;67(5):523-7. |