Ligustilide|cas 4431-01-0|DC Chemicals

Cas No.:	4431-01-0
Chemical Name:	Ligustilide
Synonyms:	Ligustilide;3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE;3-BUTYLIDENE-4,5-DIHYDROPHTHALIDE;LIGUSTILIDE, Z-;Z-LIGUSTILIDE;3-Butylidene-4,5-dihydro-1(3H)-isobenzofuranone;1(3H)-Isobenzofuranone,3-butylidene-4,5-dihydro-;(3Z)-3-Butylidene-4,5-dihydroisobenzofuran-1(3H)-one;3-Butyliden-1-oxo-1.3.4.5-tetrahydro-isobenzofuran;3-butylidene-4,5-dihydro-3H-isobenzofuran-1-one;Angelica Extract Powder;LIGUSTILIDE,Z;Angelica Extract.;(Z)-Ligustilide;cis-ligustilide;Ligustilide A;(Z)-3-Butylidene-4,5-dihydroisobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-;IQVQXVFMNOFTMU-FLIBITNWSA-N;10HE68JD06;(3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one;(3Z)-3-butylidene-4,5-dihydroisobenzofuran-1-one;trans-ligustilide;Ligustilide, (E)-;Spectrum5_000551;Ligustil
SMILES:	O1C(C2C([H])=C([H])C([H])([H])C([H])([H])C=2/C/1=C(\[H])/C([H])([H])C([H])([H])C([H])([H])[H])=O
Formula:	C₁₂H₁₄O₂
M.Wt:	190.2384
Purity:	>98%, Standard References Grade
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].

References:

[1]. Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8. [2]. Du H, et al. A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction. Se Pu. 2015 May;33(5):530-4.

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