ML18|ML18|BRS-3 antagonist

Cas No.:	1422269-30-4
Chemical Name:	(S)-3-(1H-indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
Synonyms:	ML18,ML-18,ML 18,BRS-3 antagonist,1422269-30-4
SMILES:	O=C(NC1=CC=C([N+]([O-])=O)C=C1)N[C@H](C(NCC2(C3=CC=C(OC)C=C3)CCCCC2)=O)CC4=CNC5=C4C=CC=C5
Formula:	C₃₂H₃₅N₅O₅
M.Wt:	569.67
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ML-18 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 μM.

In Vitro:

ML-18 inhibits specific 125I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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