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ML390

  Cat. No.:  DC32512   Featured
Chemical Structure
2029049-79-2
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More than 5000 active chemicals with high quality for research!
Field of application
ML390 is a human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ML390 bioactivity: ER-HOX-GFP (EC50 μM) = 1.8 ± 0.6; U937 (EC50 μM) = 8.8 ± 0.8; THP-1 (EC50 μM) = 6.5 ± 0.9; DHODH (IC50, μM) = 0.56 ± 0.1. ML390 may offer insight into the mechanism of overcoming differentiation arrest, and will translate into a starting point for a much-needed new and potent treatment for patients with acute myeloid leukemia. Inhibitors of dihydroorotate dehydrogenase (DHODH) showed activity to induce differentiation in multiple animal models of AML in vitro and in vivo. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2029049-79-2
Chemical Name: ML390
Synonyms: ML390;N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-benzamide;N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethoxy)benzamide;BDBM50201636;s8382;D71158;Q27463267;MLJ
SMILES: FC(OC1C=CC(=CC=1)C(NCCC(N[C@H]1C2C=CC=CC=2CCC1)=O)=O)(F)F
Formula: C21H21F3N2O3
M.Wt: 406.398256063461
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_14824_DC32512_2029049-79-2
COA
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