MRS-1706|A2B receptor antagonist

Cas No.:	264622-53-9
Chemical Name:	MRS-1706,MRS 1706,MRS1706
Synonyms:	MRS-1706,MRS 1706,MRS1706
SMILES:	O=C(NC1=CC=C(C(C)=O)C=C1)COC2=CC=C(C3=NC(N(CCC)C(N(CCC)C4=O)=O)=C4N3)C=C2
Formula:	C₂₇H₂₉N₅O₅
M.Wt:	503.55
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	MRS-1706 is a potent and selective A(2B) adenosine receptor antagonist with a Ki value of 1.39 nM.
In Vitro:	MRS-1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively[1]. Pretreatment with ZM241385 (A2A-Ado receptor antagonist) alone or in combination with MRS-1706 (A2B-Ado receptor antagonist) results in a pure constriction upon adenosine[2].

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