Miransertib HCl|CAS 1313883-00-9|DC Chemicals

Cas No.:	1313883-00-9
Chemical Name:	Miransertib HCl
Synonyms:	Miransertib HCl;Miransertib hydrochloride;Miransertib (hydrochloride);ARQ 092;3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine hydrochloride;ARQ092 Hydrochloride;Miransertib (ARQ 092)HCl;BCP25709;BDBM50536167;s8339;AK685840;3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine;hydrochloride;Miransertib (ARQ 092) HCl;C72257;3-(3-(4-(1-aminocyclobutyl)phenyl)-
SMILES:	Cl.NC1(C2C=CC(=CC=2)N2C(C3=CC=CN=C3N)=NC3C=CC(C4C=CC=CC=4)=NC2=3)CCC1
Formula:	C₂₇H₂₅ClN₆
M.Wt:	468.980603933334
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma.

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