Nilvadipine|cas 75530-68-6|DC Chemicals

Cas No.:	75530-68-6
Synonyms:	FK235;Escor;FR34235;Nivadil;Nivadip
SMILES:	COC(C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)=O
Formula:	C₁₉H₁₉N₃O₆
M.Wt:	385.3707
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Nilvadipine(FR34235) is a calcium channel blocker for treatment of hypertension. Nilvadipine is a new calcium antagonist of the the dihydropyridine group. Nilvadipine is mainly excreted via the kidneys in the form of inactive metabolites. Nilvadipine can be used to treat hypertensive patients who are also suffering from diabetes mellitus, lipometabolic disturbances, chronic obstructive respiratory tract disease, or cerebral circulatory disturbances. Owing to its high vascular selectivity, antiatherogenic properties, 24-h action, and good tolerance, nilvadipine fulfills the requirements for a modern antihypertensive agent. FR34235 was also the most potent among the calcium antagonists tested. The IC50 values were 3.3 × 10?11 M for FR34235. FR34235 should be useful for preventing and treating atherosclerosis. Inhibition of smooth muscle cell migration is thought to be its mechanism of antiatherogenic activity. The apparent half-maximum inhibitory concentrations (IC50s) at every 1- and 30-s stimulation were 1.9×10?6 M and 7.6×10?6 M for nilvadipine, respectively. Nilvadipine selectively inhibited the L-type Ca2+ channel current which comprised 34% of the total HVA ICa.

Cat. No.	Product name	Field of application
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DC47243	Dehydroglyasperin C	Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
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DC47140	Yadanzioside K	Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
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