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ODM-203

  Cat. No.:  DC12445   Featured
Chemical Structure
1430723-35-5
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More than 5000 active chemicals with high quality for research!
Field of application
ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1430723-35-5
Chemical Name: N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide
Synonyms: ODM203;ODM 203
SMILES: C(S(NC1C=C(N2C3=CC=C(C4=CN(C)N=C4)C=C3N=C2)C=C(C2=CC=C(F)C=C2F)C=1)(=O)=O)1CC1
Formula: C26H21F2N5O2S
M.Wt: 505.544
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].
Target: FGFR1:11 nM (IC50) FGFR2:16 nM (IC50) FGFR3:6 nM (IC50) FGFR4:35 nM (IC50) VEGFR1:26 nM (IC50) VEGFR2:9 nM (IC50) VEGFR3:5 nM (IC50) DDR1:6 nM (IC50) RET:8 nM (IC50) SIK3:23 nM (IC50) PDGFRa:35 nM (IC50) MINK1:41 nM (IC50) MAP4K4:49 nM (IC50)
References: [1]. Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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