Parbendazole|CAS 14255-87-9|DC Chemicals

Cas No.:	14255-87-9
Chemical Name:	Parbendazole
Synonyms:	Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate;5-Butyl-2-benzimidazolecarbamic acid methyl ester;5-Butyl-2-(carbomethoxyamino)benzimidazole;Parbendazole;Parbendazole-D3;5-butyl-2-benzimidazolecarbamicacimethylester;helmatac;Methyl (5-butyl-1H-benzoimidazol-2-yl)carbamate;methyl5-butyl-2-benzimidazolecarbamate;pbdz;verminum;skf29044;Parbendazole (200 mg);Parbendazole Solution, 100ppm;Worm Guard;Helatac;SKF 29044;Parbendazol [INN-Spanish];Parbendazolum [INN-Latin];METHYL 5-BUTYL-2-BENZIMIDAZOLECARBAMATE;SK&F 29044;Carbamic acid, (5-butyl-1H-benzimidazol-2-yl)-, methyl ester;N4X8WVX2UG;methyl N-(6-butyl-1H-benzimidazol-2-yl)carbam;PARBENDAZOLE;5-butyl-2-(carbomethoxyamino)benzimidazole
SMILES:	O(C([H])([H])[H])C(N([H])C1=NC2C([H])=C([H])C(=C([H])C=2N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O
Formula:	C₁₃H₁₇N₃O₂
M.Wt:	247.2930
Purity:	>98%
Publication:	[1]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261. [2]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261. [3]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. [4]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. [5]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163(3):449-55. [6]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163(3):449-55.

Description:

Parbendazole is an anthelmintic drug. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin and exhibits a broad-spectrum anthelmintic activity.

References:

[1]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261. [2]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261. [3]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. [4]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. [5]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163(3):449-55. [6]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163(3):449-55.

MSDS

COA

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2018-0101

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