SCH 546738|cas 906805-42-3|DC Chemicals

Cas No.:	906805-42-3
Synonyms:	SCH546738;SCH-546738
SMILES:	O=C(N)C1=NC(Cl)=C(N2CCN(C3CCN(CC4=CC=C(Cl)C=C4)CC3)[C@@H](CC)C2)N=C1N
Formula:	C₂₃H₃₁Cl₂N₇O
M.Wt:	492.4445
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM . in vitro: SCH 546738 at 10 nM inhibited T cell chemotaxis induced by all three CXCR3 ligands about 90%. In multiple experiments, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor was determined to be 0.4 nM. The IC50 of SCH 546738 is constant (~1 or 2 nM) and independent of the input concentrations of either [125I]hCXCL10 (25-500 pM) or [125I]hCXCL11 (12.5-250 pM), respectively. SCH 546738 has strong cross-species activities with IC50 of 1.3 nM, 6.4 nM, 5.9 nM and 4.2 nM in inhibiting the binding of [125I]hCXCL10 to CXCR3 of monkey, dog, mouse and rat origin, respectively. in vivo: SCH 546738 has a favourable pharmacokinetic profile in rodents. The plasma concentrations of SCH 546738 in Lewis rat and C57BL/6 mouse over 24 hr post-dose. The AUC (0-24 hr) is 7.7 μM.hr in Lewis rat @ 10 mg/kg (mpk) and is 12.6 μM.hr in C57BL/6 mouse @ 30 mpk. SCH 546738 attenuated disease development in a dose-dependent fashion, with significant reduction of the disease score evident at 40 mpk on days 4, 7 and 9, while it protected significantly on days 7 and 9 at 10 mpk. SCH 546738 administration at 3 mpk had no statistically significant effect on disease severity. SCH 546738 reduced the severity of the disease in a dose-dependent manner as well.

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