SU6656|SU 6656,SU-6656|DC Chemicals

Cas No.:	330161-87-0
Chemical Name:	2,3-DIHYDRO-N,N-DIMETHYL-2-OXO-3-[(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YL)METHYLENE]-1H-INDOLE-5-SULFONAMIDE
Synonyms:	SU 6656,SU-6656
SMILES:	N1C2=C(C=C(S(N(C)C)(=O)=O)C=C2)/C(=C/C2=CC3=C(N2)CCCC3)/C1=O
Formula:	C₁₉H₂₁N₃O₃S
M.Wt:	371.45
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SU 6656 is a Src family kinases inhibitor with IC50s of 280, 20, 130, 170 nM for Src, Yes, Lyn, and Fyn, respectively.

References:

[1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27. [2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26. [3]. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22. [4]. Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7. [5]. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86. [6]. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13(1):82-9.

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