Trovirdine（LY300046）|CAS 149488-17-5

Cas No.:	149488-17-5
Synonyms:	LY300046; LY-300046; LY 300046
SMILES:	C1=CC=NC(=C1)CCNC(=S)NC2=NC=C(C=C2)Br
Formula:	C₁₃H₁₃BrN₄S
M.Wt:	337.24
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS.
Target:	IC50 value: 7 nM Target: HIV-1
References:	[1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.

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