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BMS-191011

  Cat. No.:  DC42670   Featured
Chemical Structure
202821-81-6
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More than 5000 active chemicals with high quality for research!
Field of application
BMS 191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human BKCa channels when used at a concentration of 1 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 202821-81-6
Chemical Name: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Synonyms: BMS-191011; BMS 191011; BMS191011; UNII-LW7MXS978N; Bms-a.
SMILES: O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=C(O)C=CC(Cl)=C3
Formula: C16H10ClF3N2O3
M.Wt: 370.71
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2++-activated potassium (maxi-K) channel, effective in stroke models[1].
References: [1]. Romine JL, et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50(3):528-42.
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