dTAG-13|FKBP12 PROTAC dTAG-13|CAS 2064175-41-1

Cas No.:	2064175-41-1
Chemical Name:	(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Synonyms:	FKBP12 PROTAC dTAG-13
SMILES:	N(C(=O)[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)CC)1CCCC[C@@H]1C(O[C@H](C1=CC=CC=C1OCC(NCCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)=O)CCC1=CC=C(OC)C(OC)=C1)=O
Formula:	C₅₇H₆₈N₄O₁₅
M.Wt:	1049.184
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells; causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras, and an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate effects of KRASG12V loss on proteomic signaling, and demonstrate rapid degradation in vivo.

References:

References 1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441. View Related Products by Target PROTAC

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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