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F5446

  Cat. No.:  DC42710   Featured
Chemical Structure
2304465-89-0
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More than 5000 active chemicals with high quality for research!
Field of application
F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2304465-89-0
Chemical Name: 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxo-3,4,5,6-tetrahydropyrrolo[3,2-e]indole-1,7-dicarboxylate
Synonyms: F5446; F 5446; F-5446
SMILES: O=C(C1=CNC2=C1C3=C(N(S(=O)(C4=CC=C(Cl)C=C4)=O)C(C(OC)=O)=C3)C(C2=O)=O)OCC5=CC=CC=C5
Formula: C26H17ClN2O8S
M.Wt: 552.94
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
MSDS
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MSDS_26339_DC42710_2304465-89-0
COA
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Cat. No. Product name Field of application
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