γ-AA peptide P6 (Cyclic γ-AA Peptide 6)

  Cat. No.:  DC50317   Featured
γ-AA peptide P6 (Cyclic γ-AA Peptide 6)
Chemical Structure
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Field of application
γ-AA peptide P6 (Cyclic γ-AA P6) is a potent activator of E6 associated protein (E6AP). γ-AA peptide P6 can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions in vitro. γ-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome.
Cas No.:
Chemical Name: γ-AA peptide P6
SMILES: CC(C)C[C@H]1CN(CC(N)=O)C(=O)CCSCC2C=CC(=CC=2)C(=O)N[C@H](CN(CC(=O)N[C@H](CN(CC(=O)N[C@@H](CC2C=CC=CC=2)CN(CC(=O)N1)C(=O)CC1CC1)C(=O)CC1C=C(C=C(C=1)OC)OC)CC(C)C)C(=O)CC1=CC2=CC=CC=C2C=C1)CCCCN
Formula: C73H98N10O11S
M.Wt: 1323.68
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Bo Huang, et al. Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide. J Med Chem. 2022 Feb 10;65(3):2497-2506.
Description: γ-AA peptide P6 (Cyclic γ-AA P6) is a potent activator of E6 associated protein (E6AP). γ-AA peptide P6 can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions in vitro. γ-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome.
References: Bo Huang, et al. Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide. J Med Chem. 2022 Feb 10;65(3):2497-2506.
MSDS
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