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RM-046

  Cat. No.:  DC81467  
Chemical Structure
3040055-84-0
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More than 5000 active chemicals with high quality for research!
Field of application
RM-046 is an orally active, selective ternary complex inhibitor of KRASQ61H (active form). RM-046 forms a ternary complex with cyclophilin A, binds to active KRASQ61H in a non-covalent manner, blocks effector binding via steric hindrance and inhibits downstream signal transduction. RM-046 inhibits ERK phosphorylation and cancer cell proliferation, and induces sustained RAS pathway signal inhibition, anti-tumor activity and tumor regression in preclinical xenograft models. RM-046 can be used for the research of KRASQ61H mutant cancers.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 3040055-84-0
Chemical Name: RM-046
Formula: C50H64O14
M.Wt: 889.03
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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