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GW461484A

  Cat. No.:  DC70474  
Chemical Structure
401815-65-4
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More than 5000 active chemicals with high quality for research!
Field of application
GW461484A (GW-461484A) is a potent small molecule capable of restoring caspofungin sensitivity, inhibits Yck2 kinase in C. albicans, originally discovered as an inhibitor of human p38α with IC50 of 150 nM.GW461484A inhibited a very narrow spectrum of human kinases. At 1 uM, it showed >80% binding to only 10 additional human kinases out of a panel of >400 kinases.Yck2 is the proximal target of GW responsible for restoration of echinocandin sensitivity in C. albicans, potently inhibits Yck2 kinase activity in vitro and impairs the virulence of C. albicans in co-cultures and in mice.GW461484A potentiates conventional antifungals against a broad range of pathogens.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 401815-65-4
Chemical Name: GW461484A
Synonyms: GW-461484A
Formula: C19H14FN3
M.Wt: 303.34
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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