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KCC009

  Cat. No.:  DC71242   Featured
Chemical Structure
744198-19-4
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More than 5000 active chemicals with high quality for research!
Field of application
KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 744198-19-4
Chemical Name: Nalpha-[(benzyloxy)carbonyl]-N-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methyl]-L-tyrosinamide
SMILES: OC1=CC=C(C=C1)CC(NC(=O)OCC2=CC=CC=C2)C(=O)NCC3CC(Br)=NO3
Formula: C21H22BrN3O5
M.Wt: 476.3205
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization[1][2].
In Vitro: The inhibition rates were 15.33±1.46 (%) for H1299/WT-p53 cells, and 14.31±1.90 (%) for H1299/M175H-p53 cells when cells were treated with KCC009 at concentration of 3.91 uM[1].
References: [1]. Sheng Huaying, et al. Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells. Med Sci Monit. 2016 Dec 21;22:5041-5048. [2]. L Yuan, et al. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene
MSDS
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MSDS_35468_DC71242_744198-19-4
COA
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