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ML148

  Cat. No.:  DC43508   Featured
Chemical Structure
451496-96-1
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More than 5000 active chemicals with high quality for research!
Field of application
Potent, selective, and  competitive 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) inhibitor
Cas No.: 451496-96-1
Chemical Name: [1-(3-Methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
Synonyms: spudl 02614;piperidin-1-yl(1-m-tolyl-1H-indazol-6-yl)methanone;[1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone;SMR000031475;MLS000095927;ML148;[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone;1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-benzimidazole;Oprea1_076954;MLS002729014;IFLab1_004318;cid_3243760;BDBM30884;AOB1532;HMS1424E06;HMS2460B17;IDI1_010073;[1-(m-tolyl)benzimidazol-5-yl]-piperidino-methanone;Q
SMILES: O=C(C1C([H])=C([H])C2=C(C=1[H])N=C([H])N2C1=C([H])C([H])=C([H])C(C([H])([H])[H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
Formula: C20H21N3O
M.Wt: 319.4002
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
MSDS
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MSDS_27129_DC43508_451496-96-1
COA
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Cat. No. Product name Field of application
DC82301 IC-8 IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
DC75721 CL2A-SN38 (Govitecan) CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
DCC4995 Szu101 Novel TLR7 agonist via immune response induction and tumor microenvironment modulation
DCC3219 Malp-2 Toll-like receptor 2/6 (TLR-2/6) agonist, regulating Lcn2 gene, promoting collateral growth
DC72823 SU056 SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.
DC72724 PTC258 PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model.
DC72507 VT-1598 tosylate VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris.
DC72432 DSPE-N3 DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical.
DC72429 DSPE-glutaric acid DSPE-glutaric acid is a lipid. DSPE-glutaric acid can be used for the research of various biochemical.
DC71975 TriGalNAc CBz TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies.
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