nor-NOHA acetate|CAS 1140844-63-8|DC Chemicals

Cas No.:	1140844-63-8
Chemical Name:	nor-NOHA acetate
Synonyms:	nor-NOHA, 2CH3CO2H;nor-NOHA acetate;Nomega-Hydroxy-nor-L-arginine, Diacetate Salt;L-2-Amino-(4-(2′-hydroxyguanidino)butyric Acid, 2CH3CO2H;N-Omega-hydroxy-l-norarginine diacetate salt;N?-Hydroxy-L-norarginine diacetate salt;Nω-Hydroxy-nor-L-arginine acetate
SMILES:	OC([C@H](CC/N=C(\N)/NO)N)=O.OC(C)=O.OC(C)=O
Formula:	C₉H₂₀N₄O₇
M.Wt:	296.277702331543
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].
Target:	Arginase[1]
References:	[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.

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