Bendamustine HCL (SDX-105, Cytostasane)|supplier DC Chemicals

Cas No.:	3543-75-7
Chemical Name:	Bendamustine HCl
Synonyms:	4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride;BENDAMUSTIN HYDROCHLORIDE;CYTOSTASAN;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryric acid hydrochloride;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryricacihydrochlor;gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydro;BENDAMUSTINE HCL;4-[5-[Bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butyric acid hydrochloride;Bendamustine hydrochloride hydrate;4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo-[d]imidazol-2-yl)butanoic acid hydrochloride;Bendamustine hydrochloride;REMODULIN;BendaMustin HCl;Bendamustinhydrochlorid;Bendamustinum;CytostasanHCl;EP3101;EP-3101;Ribomustin;SDX105;SDX-105;Treanda;ZIMET-33;IMET 3393;Treakisym;Bendamustine (hydrochloride);Bendeka;SDX 105;981Y8SX18M;Ribomustine;Levact;Treanda (TN);gamma(1-Methyl-5;1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride;NCGC00261308-01;BENDAMUSTINE HYDROCHLORIDE [MI];BCP02107;Hydrochloride, Bendamustine;2-Benzimidazolebutyric acid, monohydrochloride;Ribomustin (TN);Cytostasan Hydrochloride;CHEMBL1201734;VIVIMUSTA;4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-yl]butanoic acid monohydrochloride;Bendamustine HCL (SDX-105, Cytostasane);SCHEMBL18843;2-Benzimidazolebutyric acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride;BENDAMUSTINE HYDROCHLORIDE [USP-RS];Bendamustin hydrochloride;BCP9000390;BENDAMUSTINE HYDROCHLORIDE (MART.);AS-15856;Belrapzo;HY-B0077;Z2235802251;2-Benzimidazolinebutryric acid, hydrochloride;Cytostasan;Bendamustine Hydrochloride Injection;NSC-138783;AKOS015951203;Cytostosan;4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzoimidazol-2-yl)butanoic acid monohydrochloride;Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionicacid;SW219266-1;Bendit;Bendamustine HCl;BENDAMUSTINE HYDROCHLORIDE (USP-RS);CS-1771;5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl;FT-0650624;2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride;SMR004234484;BCPP000348;BENDAMUSTINE HYDROCHLORIDE [WHO-DD];4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoicacidhydrochloride;Treanda HCl;MLS006010156;AM20090666;Bendamustine hydrochloride [USAN:JAN];Symbenda;NSC 138783;CCG-221927;BENDAMUSTINE HYDROCHLORIDE (USP MONOGRAPH);5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride;SyB L-0501;1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride;MFCD01658758;5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride;B4033;3543-75-7 (HCl);BENDAMUSTINE HYDROCHLORIDE [USAN];SB17462;ZIMET 33/93;BP-25399;1H-Benzimidazole-2-butanoic ...
SMILES:	ClC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])Cl)C1C([H])=C([H])C2=C(C=1[H])N=C(C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])N2C([H])([H])[H].Cl[H]
Formula:	C₁₆H₂₂Cl₃N₃O₂
M.Wt:	394.72
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. Bendamstine was approved in USA in March 2008.For the detailed information of Bendamustine HCL (SDX-105, Cytostasane), the solubility of Bendamustine HCL (SDX-105, Cytostasane) in water, the solubility of Bendamustine HCL (SDX-105, Cytostasane) in DMSO, the solubility of Bendamustine HCL (SDX-105, Cytostasane) in PBS buffer, the animal experiment (test) of Bendamustine HCL (SDX-105, Cytostasane), the cell expriment (test) of Bendamustine HCL (SDX-105, Cytostasane), the in vivo, in vitro and clinical trial test of Bendamustine HCL (SDX-105, Cytostasane), the EC50, IC50,and Affinity of Bendamustine HCL (SDX-105, Cytostasane), Please contact DC Chemicals.

MSDS

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2018-0101

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